Endocytosis Mechanism of Nano Metal-Organic Frameworks for Drug Delivery
نویسندگان
چکیده
منابع مشابه
Amorphous metal-organic frameworks for drug delivery.
We report the encapsulation of the hydrophilic model molecule calcein in the Zr-based MOF UiO-66, followed by amorphization of the framework by ball-milling. We show controlled release of calcein over more than 30 days, compared with the 2 day release period from crystalline UiO-66.
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BACKGROUND Metal organic frameworks (MOFs) have attracted more attention in the last decade because of a suitable pore size, large surface area, and high pore volume. Developing biocompatible MOFs such as the MIL family as a drug delivery system is possible. PURPOSE Flurbiprofen (FBP), a nonsteroidal anti-inflammatory agent, is practically insoluble in aqueous solution, and, therefore, needs ...
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A critical bottleneck for the use of metal-organic frameworks (MOFs) as drug delivery systems has been allowing them to reach their intracellular targets without being degraded in the acidic environment of the lysosomes. Cells take up particles by endocytosis through multiple biochemical pathways, and the fate of these particles depends on these routes of entry. Here, we show the effect of func...
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Metal organic frameworks (MOFs), an emerging class of crystalline nanoporous materials, have recently caught attention for their unique properties such as high surface area, large pore volume, high uniform and permanent porosity, and ease of chemical tenability to introduce additional physical, chemical, or electrical properties. MOFs constructed from inorganic and organic pieces: metal ions an...
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The drug olsalazine (H4olz) was employed as a ligand to synthesize a new series of mesoporous metal-organic frameworks that are expanded analogues of the well-known M2(dobdc) materials (dobdc(4-) = 2,5-dioxido-1,4-benzenedicarboxylate; M-MOF-74). The M2(olz) frameworks (M = Mg, Fe, Co, Ni, and Zn) exhibit high surface areas with large hexagonal pore apertures that are approximately 27 Å in diam...
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ژورنال
عنوان ژورنال: Advanced Healthcare Materials
سال: 2016
ISSN: 2192-2640
DOI: 10.1002/adhm.201600296